Description

(R)-2,2-Dimethyl-1,3-Dioxolane-4-Acetonitrile CAS NO 74923-97-0 is a high-value chiral building block and protected cyanohydrin derivative, essential for the stereoselective synthesis of complex molecules. Its primary value lies in providing a versatile, enantiomerically pure intermediate that allows for the controlled introduction of functional groups while preserving stereochemical integrity. This compound is critically needed by research and development chemists and process engineers in the pharmaceutical and fine chemical industries for the production of active pharmaceutical ingredients (APIs), natural products, and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-blockers, antiviral agents, and other enantiomerically pure drugs.
• Asymmetric Synthesis: Used in nucleophilic addition reactions and as a precursor for chiral amino alcohols and hydroxy acids.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products with defined stereochemistry.
• Agrochemical Research: Employed in developing chiral pesticides and herbicides where specific stereoisomers exhibit enhanced biological activity.
• Ligand and Catalyst Preparation: A precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or epoxidation reactions.
• Material Science: Potential use in the synthesis of chiral polymers or liquid crystals with specific optical properties.

Basic Information

Product Name	(R)-2,2-Dimethyl-1,3-Dioxolane-4-Acetonitrile
CAS No.	74923-97-0
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-acetonitrile; (R)-2,2-Dimethyl-4-cyanomethyl-1,3-dioxolane; (R)-4-(Cyanomethyl)-2,2-dimethyl-1,3-dioxolane; (R)-Acetonitrile, 2,2-dimethyl-1,3-dioxolane-4-; (R)-DMDAN; (R)-Glyceraldehyde Acetonide Cyanohydrin; (R)-O-Isopropylidene Glyceraldehyde Cyanohydrin; (R)-1,3-Dioxolane-4-acetonitrile, 2,2-dimethyl-
EINECS	Contact for details

Quality Control

Our (R)-2,2-Dimethyl-1,3-Dioxolane-4-Acetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including HPLC for chemical purity and chiral analysis to confirm enantiomeric excess (e.e.). Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.440
Specific Rotation ([α]20D)	-15° to -20° (c=1 in CHCl3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.