Description

(1-Methylethyl)Bis[Methyl(1-Methylethyl)Cyclohexyl]Phosphine is a specialized, sterically hindered tertiary phosphine ligand, a critical component in advanced catalytic systems. Its primary value lies in enabling highly selective and efficient transition metal-catalyzed reactions, particularly in fine chemical and pharmaceutical synthesis. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over reaction pathways to create complex, high-value molecules. CAS No. 74779-92-3.

Application

• Cross-Coupling Catalysis: A key ligand in palladium-catalyzed Suzuki-Miyaura, Heck, and Negishi cross-coupling reactions for C-C bond formation.
• Asymmetric Hydrogenation: Used in chiral ruthenium or rhodium complexes for the enantioselective synthesis of pharmaceutical intermediates and active ingredients.
• Hydroformylation: Acts as a ligand in rhodium-catalyzed hydroformylation processes to produce aldehydes from olefins.
• Olefin Metathesis: Employed as a supporting ligand in Grubbs-type catalysts for ring-closing metathesis (RCM) and cross-metathesis applications.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of complex, sterically demanding molecules in API (Active Pharmaceutical Ingredient) development.
• Agrochemical Manufacturing: Used in the synthesis of advanced, high-performance crop protection agents.
• Material Science Research: Applied in the development of novel organometallic complexes and polymers with tailored properties.
• Academic & Industrial R&D: A valuable tool for exploring new catalytic methodologies and reaction mechanisms in laboratory settings.

Basic Information

Item	Details
Product Name	(1-Methylethyl)Bis[Methyl(1-Methylethyl)Cyclohexyl]Phosphine
CAS No.	74779-92-3
Molecular Formula	C24H49P
Molecular Weight	368.62 g/mol
Synonyms	Bis(methylisopropylcyclohexyl)(isopropyl)phosphine; Di(1-methyl-1-isopropylcyclohexyl)(isopropyl)phosphine; Isopropylbis(1-methyl-1-isopropylcyclohexyl)phosphine; (i-Pr)Cyp2P; (i-Pr)PCyp2; Cyp2P(i-Pr); Tertiary phosphine ligand Cyp2P(i-Pr); Sterically hindered trialkylphosphine
EINECS	Contact for details

Quality Control

Our production of (1-Methylethyl)Bis[Methyl(1-Methylethyl)Cyclohexyl]Phosphine adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized using advanced analytical techniques including NMR (1H, 13C, 31P), GC, and HPLC to verify identity, purity, and the absence of critical impurities like phosphine oxides. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 15-25°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
31P NMR Purity	≥ 98.0%
Phosphine Oxide Content	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.