Description

n-(Guanosin-8-Yl)-4-Aminobiphenyl is a specialized biochemical compound, a guanosine adduct formed with the aromatic amine 4-aminobiphenyl. This compound is of significant importance in research and analytical chemistry, particularly for studying DNA damage and adduct formation. It serves as a critical reference standard and reagent for scientists in toxicology, carcinogenesis research, and analytical method development, enabling precise quantification and understanding of exposure biomarkers.

Application

• Biomarker Research: Used as a certified reference material for the quantification of DNA adducts in biological samples, a key indicator of exposure to aromatic amines.
• Toxicology Studies: Essential for in vitro and in vivo studies investigating the metabolic activation, genotoxicity, and carcinogenic mechanisms of 4-aminobiphenyl and related compounds.
• Analytical Method Development: Serves as a primary standard for calibrating sophisticated analytical instruments like LC-MS/MS and HPLC for high-sensitivity detection of adducts.
• Cancer Research: Employed in studies exploring the molecular etiology of cancers linked to aromatic amine exposure, such as bladder cancer.
• Quality Control in Laboratories: Used to validate and ensure the accuracy of analytical procedures in contract research organizations (CROs) and diagnostic labs.
• Regulatory Science: Supports safety assessments and compliance testing for industries handling aromatic amines, providing a benchmark for exposure monitoring.

Basic Information

Product Name	n-(Guanosin-8-Yl)-4-Aminobiphenyl
CAS No.	74764-35-5
Molecular Formula	C₂₂H₂₁N₇O₅
Molecular Weight	463.45 g/mol
Synonyms	8-(4-Biphenylylamino)guanosine; N-(Guanosin-8-yl)-4-aminobiphenyl; 4-Aminobiphenyl-guanosine adduct; ABP-Gua; Guanine-ABP adduct; DNA-4-Aminobiphenyl Adduct Standard; 8-(4-Aminobiphenyl-1-yl)guanosine
EINECS	Contact for details

Quality Control

Every batch of n-(Guanosin-8-Yl)-4-Aminobiphenyl is produced and analyzed under strict quality protocols to ensure the highest standards of purity and identity, critical for research integrity. We provide comprehensive Certificates of Analysis (COA) detailing purity, chromatographic data, and spectroscopic confirmation. Our quality system is designed to meet the rigorous demands of analytical and research laboratories, ensuring traceability and reproducibility in your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere or with desiccant after opening to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.