Description

Geclosporin CAS NO 74436-00-3 is a specialized chemical compound belonging to the cyclosporin class, known for its potent biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the field of immunology. It serves as an essential building block for researchers and manufacturers developing advanced therapeutic agents targeting autoimmune diseases and organ transplant rejection.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel immunosuppressive drugs and related therapeutic compounds.
• Biochemical Research: Used in laboratory studies to investigate T-cell function, cytokine modulation, and intracellular signaling pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Drug Discovery: Employed in medicinal chemistry programs to develop new analogs with improved efficacy and safety profiles.
• API Synthesis: Integral in the multi-step manufacturing process of Active Pharmaceutical Ingredients (APIs) within the immunosuppressant category.

Basic Information

Product Name	Geclosporin
CAS No.	74436-00-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cyclosporin G; [Thr2, Leu5, D-Hiv8, Leu10]-Cyclosporin A; OG 37-325; IMM 125; (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoic Acid Cyclosporin Derivative
EINECS	Contact for details

Quality Control

Our Geclosporin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced chromatographic techniques. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.