Description

17A-Hydroxy-11-Deoxycorticosterone-*(1,2-3H(N)) is a high-specific-activity tritium-labeled derivative of the steroid hormone 11-deoxycorticosterone, a key intermediate in corticosteroid biosynthesis. This radiolabeled compound is essential for advanced research and development, enabling precise metabolic pathway tracing, receptor binding studies, and analytical method development. It is a critical tool for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on endocrinology, steroid metabolism, and drug discovery.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to study the biosynthesis and metabolic fate of corticosteroids in in vitro and in vivo systems.
• Receptor Binding Assays: Employed in competitive binding studies to characterize and quantify mineralocorticoid receptor (MR) activity and affinity.
• Analytical Reference Standard: Serves as a critical internal standard in LC-MS/MS and HPLC methods for the quantification of steroid hormones in biological matrices.
• Enzyme Kinetics Studies: Utilized to investigate the activity of enzymes like 11β-hydroxylase and 21-hydroxylase in steroidogenic pathways.
• Pharmaceutical R&D: Supports the discovery and development of novel therapeutics targeting hypertension, adrenal disorders, and related endocrine conditions.
• Clinical Research: Aids in diagnostic assay development for conditions like congenital adrenal hyperplasia (CAH).

Basic Information

Product Name	17A-Hydroxy-11-Deoxycorticosterone-*(1,2-3H(N))
CAS No.	74340-35-5
Molecular Formula	C21H283H2O4 (Tritiated Form)
Molecular Weight	~ 364.5 g/mol (for tritiated form)
Synonyms	17α-Hydroxy-11-deoxycorticosterone; 17α-Hydroxy-21-hydroxypregn-4-ene-3,20-dione; 17α-OH-DOC; [1,2-3H]-17α-Hydroxy-11-deoxycorticosterone; 17α-Hydroxycortexone; Tritiated 17α-OH-DOC; 17α-Hydroxy-11-desoxycorticosterone; 17α-Hydroxydeoxycorticosterone
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is produced and tested under a strict quality management system. The product undergoes rigorous analytical verification to ensure chemical purity, radiochemical purity (typically >97% by HPLC), and specified specific activity. Full traceability is maintained, and a comprehensive Certificate of Analysis (COA) detailing identity, purity, radioactivity concentration, and solvent composition is provided with each shipment.

Storage

Preserve in the original manufacturer's container as supplied. Store at -20°C or below. The product is strictly light-sensitive (protect from all light exposure) and highly volatile. Store in a dedicated, well-ventilated area for radioactive materials, in accordance with local and international radiation safety regulations.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Contact for details (Typical range: 40-80 Ci/mmol)
Radioactivity Concentration	As stated on label (e.g., 1 mCi/mL)
Solvent	Ethanol or Benzene:Ethanol (as specified)
Chemical Purity (HPLC)	≥ 95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.