Description

L-Leucine-1-13C is a stable isotope-labeled analog of the essential amino acid L-Leucine, specifically enriched with carbon-13 at the 1-position. This precise labeling is critical for advanced analytical techniques, providing researchers and manufacturers with a reliable internal standard for accurate quantification and metabolic pathway tracing. It is an indispensable tool for professionals in pharmaceutical research, clinical diagnostics, and nutritional science who require high-fidelity isotopic tracers.

Application

• Stable Isotope Dilution Mass Spectrometry (SID-MS): Serves as an internal standard for the precise quantification of L-Leucine in complex biological matrices like plasma, tissues, and cell cultures.
• Metabolic Flux Analysis (MFA): Used to trace and model carbon flow through metabolic pathways, particularly in studies of protein metabolism, muscle physiology, and cancer cell energetics.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the incorporation of amino acids into novel therapeutic peptides and proteins.
• Clinical Research: Facilitates in vivo metabolic studies in humans to understand conditions like metabolic disorders, muscle wasting diseases, and liver function.
• Nutritional Science: Used to investigate protein synthesis, turnover, and the metabolic fate of dietary amino acids in both animal and human studies.
• Biomarker Discovery & Validation: Aids in the development and validation of mass spectrometry-based assays for diagnostic biomarkers related to amino acid metabolism.

Basic Information

Product Name	L-Leucine-1-13C
CAS No.	74292-94-7
Molecular Formula	C513CH13NO2
Molecular Weight	132.16 g/mol
Synonyms	(2S)-2-Amino-4-methyl-1-13C-pentanoic acid; L-(1-13C)Leucine; (S)-2-Amino-4-methyl-1-13C-valeric acid; H-13C-Leu-OH; Leucine-1-13C; L-Leucine (1-13C); [1-13C]-L-Leucine
EINECS	Contact for details

Quality Control

Every batch of L-Leucine-1-13C is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), chiral purity, and other critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chiral Purity ([α]D)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.