Description

Ethyl 4-Amino-2-Fluorobenzoate is a high-purity fluorinated benzoate ester derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both an amino and a fluorine substituent, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic components in electronic materials, contributing to improved performance in display and lighting technologies.
• Dye & Pigment Manufacturing: Employed in the production of specialized fluorinated dyes and pigments, offering enhanced color fastness and unique optical properties.
• Cross-Coupling Reactions: The amino and ester groups make it a suitable substrate for palladium-catalyzed reactions like Buchwald-Hartwig amination and Suzuki coupling, enabling rapid diversification of chemical libraries.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and process research in academic institutions and contract research organizations (CROs).

Basic Information

Product Name	Ethyl 4-Amino-2-Fluorobenzoate
CAS No.	73792-06-0
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	4-Amino-2-fluorobenzoic acid ethyl ester; Ethyl 4-amino-2-fluorobenzoate; 2-Fluoro-4-aminobenzoic acid ethyl ester; Benzoic acid, 4-amino-2-fluoro-, ethyl ester; Ethyl p-amino-o-fluorobenzoate; 4-Amino-2-fluorobenzoic acid, ethyl ester; Ethyl 2-fluoro-4-aminobenzoate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Amino-2-Fluorobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation. For long-term storage, consider using an inert atmosphere to mitigate potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.