Description

Ethyl 3,4-Difluorobenzoylformate is a high-value fluorinated aromatic ester, serving as a critical advanced intermediate in modern synthetic chemistry. Its primary commercial importance lies in its role as a versatile building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce difluorinated aromatic motifs with high precision.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluorobenzoyl moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving performance characteristics.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and specialty chemicals with tailored properties.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Ethyl 3,4-Difluorobenzoylformate
CAS No.	73790-05-3
Molecular Formula	C10H8F2O3
Molecular Weight	214.17 g/mol
Synonyms	Ethyl 3,4-difluoro-α-oxobenzeneacetate; Ethyl (3,4-difluorophenyl)(oxo)acetate; 3,4-Difluorobenzoylformic Acid Ethyl Ester; Ethyl 2-oxo-2-(3,4-difluorophenyl)acetate; α-Oxo-3,4-difluorobenzeneacetic Acid Ethyl Ester; Ethyl α-oxo-3,4-difluorobenzeneacetate; Ethyl 2-(3,4-difluorophenyl)-2-oxoacetate
EINECS	Contact for details

Quality Control

Our Ethyl 3,4-Difluorobenzoylformate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong alkalis. The container must be kept tightly closed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.