Description

L-Leucine-18O2 is a stable isotope-labeled analog of the essential amino acid L-Leucine, specifically enriched with two oxygen-18 atoms. This compound is critical for advanced research and development, providing a non-radioactive tracer for precise metabolic and pharmacokinetic studies. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and academic research sectors for applications in mass spectrometry, proteomics, and metabolic pathway analysis.

Application

• Biomedical Research Tracer: Used as an internal standard in quantitative mass spectrometry (MS) for accurate protein and metabolite quantification.
• Metabolic Flux Analysis: Enables the detailed tracking and modeling of amino acid metabolism and protein synthesis rates in cell cultures and biological systems.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to trace the fate of drug compounds and their metabolites.
• Proteomics & Biomarker Discovery: Facilitates relative and absolute protein quantification in complex biological samples using techniques like SILAC (Stable Isotope Labeling by Amino acids in Cell culture).
• Nutritional Science Research: Used to study leucine turnover, muscle protein synthesis, and the metabolic effects of dietary supplements.
• Quality Control Reference Standard: Serves as a certified reference material for calibrating analytical instruments and validating methods in quality control laboratories.

Basic Information

Item	Details
Product Name	L-Leucine-18O2
CAS No.	73579-45-0
Molecular Formula	C6H1318O2N
Molecular Weight	135.16 g/mol (approx.)
Synonyms	(2S)-2-Amino-4-methylpentanoic-18O2 acid; L-Leucine-18O2; (S)-2-Amino-4-methylpentanoic-18O2 acid; Leucine-18O2; (S)-Leucine-18O2; Stable Isotope Labeled L-Leucine; L-Leucine (oxygen-18O2); 18O2-L-Leucine
EINECS	Contact for details

Quality Control

Our L-Leucine-18O2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, isotopic enrichment analysis via mass spectrometry, and chiral purity verification to ensure the specified enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 18O
Chemical Purity	≥ 99.0%
Specific Rotation	+14.5° to +16.5° (c=2 in 6N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.