Description

(-)-Leukotriene A4 Methyl Ester is a high-purity, stereochemically defined synthetic intermediate of significant biological importance. This compound is critical for research into the leukotriene pathway, a key mediator in inflammatory and allergic responses. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in developing novel anti-inflammatory therapeutics and studying eicosanoid biochemistry.

Application

• Biochemical Research: A vital reference standard and precursor for studying leukotriene biosynthesis, metabolism, and biological activity.
• Pharmaceutical Development: Serves as a key synthetic intermediate in the research and development of leukotriene receptor antagonists and biosynthesis inhibitors.
• Inflammation & Immunology Studies: Used in cellular and in vitro assays to model and investigate inflammatory pathways related to asthma, allergies, and other immune-mediated conditions.
• Metabolite Synthesis: Essential for the chemical synthesis of downstream leukotriene metabolites, such as LTB4, LTC4, LTD4, and LTE4, for biological testing.
• Analytical Standard: Employed as a certified reference material (CRM) in HPLC, LC-MS, and other analytical methods for the quantification of leukotrienes in biological samples.
• Enzymology Studies: Used as a substrate for enzymes like LTA4 hydrolase and LTC4 synthase to study enzyme kinetics and inhibition.

Basic Information

Product Name	(-)-Leukotriene A4 Methyl Ester
CAS No.	73466-12-3
Molecular Formula	C21H32O3
Molecular Weight	332.48 g/mol
Synonyms	(5S,6S)-5,6-Epoxy-7,9,11,14-eicosatetraenoic Acid Methyl Ester; Leukotriene A4 Methyl Ester; LTA4 Methyl Ester; Methyl (5S,6S)-Oxido-7E,9E,11Z,14Z-eicosatetraenoate; (5S-trans)-5,6-Epoxy-7,9,11,14-eicosatetraenoic Acid Methyl Ester; (-)-LTA4 Methyl Ester; 5(6)-Epoxy-7,9,11,14-eicosatetraenoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (-)-Leukotriene A4 Methyl Ester is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity	≥ 98% (5S,6S isomer)
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.