Description

(-)-2,3-o-Isopropylidene-D-Threitol is a high-purity, chiral building block and protecting group reagent essential for asymmetric synthesis. This compound is valued for its role in constructing complex molecules with defined stereochemistry, ensuring high enantiomeric purity in final products. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries developing active ingredients and specialty chemicals.

Application

• Chiral Auxiliary and Ligand Precursor: Used in the synthesis of chiral ligands for asymmetric catalysis.
• Pharmaceutical Intermediate: A key building block for nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Natural Product Synthesis: Employed in the stereoselective synthesis of complex natural products and sugars.
• Protecting Group Chemistry: The isopropylidene group effectively protects diol functionalities during multi-step synthetic sequences.
• Agrochemical Research: Serves as an intermediate in developing chiral pesticides and herbicides.
• Material Science: Potential monomer or modifier for creating polymers with specific chiral properties.

Basic Information

Product Name	(-)-2,3-o-Isopropylidene-D-Threitol
CAS No.	73346-74-4
Molecular Formula	C7H14O4
Molecular Weight	162.18 g/mol
Synonyms	D-(-)-2,3-O-Isopropylidene-1,4-dihydroxybutane; (2R,3R)-2,3-O-Isopropylidene-1,2,3,4-butanetetrol; (2R,3R)-1,2,3,4-Butanetetrol, 2,3-O-(1-methylethylidene)-; D-Threitol 2,3-acetonide; (-)-D-Threitol 2,3-O-isopropylidene acetal; (2R,3R)-2,3-Isopropylidenedioxybutane-1,4-diol
EINECS	Contact for details

Quality Control

Our (-)-2,3-o-Isopropylidene-D-Threitol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with high-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Specified range
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.