Description

Menaquinone 4 2,3-Epoxide is a specific epoxide derivative of menaquinone-4 (MK-4), a form of Vitamin K2. This compound serves as a crucial intermediate and reference standard in pharmaceutical research and the synthesis of bioactive Vitamin K analogs. It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers focused on cardiovascular and bone health therapeutics. The precise chemical structure of this epoxide makes it valuable for metabolic studies and quality control in the production of high-grade Vitamin K2 products.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the manufacture of menaquinone-4 (Vitamin K2) and its derivatives.
• Biochemical Research: Used as a reference standard and probe in studies of Vitamin K metabolism, particularly the Vitamin K cycle.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and other analytical methods.
• Nutraceutical Development: Employed in R&D for formulating advanced Vitamin K2 supplements with specific bioavailability profiles.
• Metabolite Studies: Essential for investigating the biological activity and metabolic pathways of Vitamin K2 in preclinical models.

Basic Information

Product Name	Menaquinone 4 2,3-Epoxide
CAS No.	72908-86-2
Molecular Formula	C31H40O3
Molecular Weight	460.65 g/mol
Synonyms	Vitamin K2 2,3-Epoxide; MK-4 2,3-Epoxide; 2,3-Epoxymenatetrenone; 2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoquinone 2,3-epoxide; Menatetrenone Epoxide; (2E,6E,10E)-2-[(2R,3R)-3-Methyl-3,4-epoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraene
EINECS	Contact for details

Quality Control

Our Menaquinone 4 2,3-Epoxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We can support development projects requiring compliance with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.