Description

Neplanocin A is a potent adenosine analog and carbocyclic nucleoside with significant biological activity. This compound is a valuable research tool and pharmaceutical intermediate due to its mechanism as an S-adenosylhomocysteine hydrolase inhibitor. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors. The material is supplied as a high-purity standard to support advanced drug discovery and biochemical studies.

Application

• Biochemical Research: Used as a potent and specific inhibitor of S-adenosylhomocysteine (SAH) hydrolase in enzymatic and cellular studies.
• Antiviral Research: Investigated for its broad-spectrum antiviral activity against various viruses, serving as a key reference compound.
• Anticancer Research: Studied for its antiproliferative and cytotoxic effects in various cancer cell lines, aiding in oncology drug discovery.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based therapeutics.
• Epigenetics Research: Employed to modulate cellular methylation processes by affecting the SAH/AdoHcy ratio.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for HPLC and LC-MS.

Basic Information

Product Name	Neplanocin A
CAS No.	72877-50-0
Molecular Formula	C11H13N5O3
Molecular Weight	263.25 g/mol
Synonyms	(–)-Neplanocin A; 9-[(1R,2S,3R)-2,3-Dihydroxy-4-(hydroxymethyl)cyclopent-4-en-1-yl]adenine; 3-Deazaneplanocin A precursor; Carbocyclic 3-deazaadenosine analog; NSC 377364; SAH Hydrolase Inhibitor I; c3-Npc A
EINECS	Contact for details

Quality Control

Every batch of Neplanocin A is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.