Description

(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester is a high-purity chiral building block and intermediate of significant value in asymmetric synthesis. Its enantiomerically pure form is critical for imparting specific stereochemistry in the production of advanced pharmaceutical compounds and fine chemicals. This product is essential for R&D and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop or produce optically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting cardiovascular, metabolic, and central nervous system disorders.
• Asymmetric Synthesis: Used as a versatile chiral precursor in stereoselective reactions, including alkylations, reductions, and cross-couplings, to construct complex molecular architectures.
• Agrochemicals: Serves as a building block for the production of enantiomerically pure herbicides, fungicides, and plant growth regulators, where specific stereochemistry can influence bioactivity and environmental safety.
• Ligand and Catalyst Development: Employed in the research and preparation of chiral ligands and organocatalysts for use in homogeneous catalysis.
• Fine Chemical Synthesis: A valuable intermediate for manufacturing specialty chemicals, flavors, and fragrances that require precise stereochemical control.
• Academic and Industrial R&D: Used in research laboratories for methodological development in organic synthesis and for exploring new chemical entities.

Basic Information

Product Name	(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester
CAS No.	72657-23-9
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	(R)-(-)-Methyl 3-Hydroxy-2-Methylpropionate; (R)-Methyl 3-Hydroxyisobutyrate; (R)-(-)-Methyl 3-Hydroxy-2-methylpropanoate; (R)-Methyl 3-Hydroxy-2-methylpropanoate; (R)-3-Hydroxy-2-methylpropionic acid methyl ester; Methyl (R)-(-)-3-hydroxy-2-methylpropionate; (2R)-3-Hydroxy-2-methylpropanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC/GC), identity confirmation (IR, NMR), and determination of chemical purity and residual solvents to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.