Description

(R)-2-Hydroxymethylbutanoic Acid is a chiral building block of significant importance in asymmetric synthesis. Its value lies in its ability to introduce both a carboxylic acid and a hydroxymethyl functional group with defined stereochemistry, enabling the construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity chiral intermediates for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is crucial for bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Peptide Mimetics and Modifications: Incorporated into peptide chains to create analogs with enhanced stability or specific biological properties.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring precise stereochemical control.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research laboratories.

Basic Information

Product Name	(R)-2-Hydroxymethylbutanoic Acid
CAS No.	72604-79-6
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	(R)-2-(Hydroxymethyl)butyric Acid; (R)-2-Hydroxymethylbutyric Acid; (R)-2-Methylolbutanoic Acid; (2R)-2-(Hydroxymethyl)butanoic Acid; D-2-Hydroxymethylbutanoic Acid; (R)-HMB; (R)-2-HMBA; (R)-Homoserine Lactone Hydrolysis Derivative
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxymethylbutanoic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.