Description

2-Deoxy-D-Glucose-1-14C is a radiolabeled analog of glucose where a carbon-14 isotope is incorporated at the C-1 position. This compound is a critical tool for metabolic research, enabling the precise tracing and quantification of glucose uptake and glycolytic flux in biological systems. It is essential for researchers and scientists in the fields of oncology, neurology, and metabolic disease studies, particularly for in vitro assays and autoradiography.

Application

• Metabolic Pathway Tracing: Used as a tracer to study glucose uptake, hexokinase activity, and glycolysis inhibition in cell cultures and tissue samples.
• Cancer Research: Employed in assays to investigate the Warburg effect and to screen for potential chemotherapeutic agents that target cancer cell metabolism.
• Neurological Studies: Applied in research on brain energy metabolism, neuronal activity, and conditions like Alzheimer's disease and epilepsy.
• Drug Discovery & Development: Serves as a key reagent in high-throughput screening for compounds that modulate glucose metabolism.
• Autoradiography & Imaging: Facilitates the visualization and spatial mapping of glucose utilization in histological sections.
• Biochemical Research: Used in enzyme kinetics studies related to glycolysis and glucose metabolism.

Basic Information

Product Name	2-Deoxy-D-Glucose-1-14C
CAS No.	72561-26-3
Molecular Formula	C6H12O5 (with 14C at C-1)
Molecular Weight	~164.16 g/mol (specific activity dependent)
Synonyms	2-Deoxy-D-[1-14C]glucose; [1-14C]-2-Deoxy-D-glucose; 1-14C-2-Deoxyglucose; 2-DG-1-14C; D-[1-14C]-2-Deoxyglucose; 2-Deoxy-D-arabino-hexose-1-14C; Radiolabeled 2-Deoxyglucose; Glycolysis Inhibitor-1-14C
EINECS	Contact for details

Quality Control

Every batch of 2-Deoxy-D-Glucose-1-14C is manufactured and analyzed under strict quality systems. We ensure high radiochemical purity and specific activity through advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity, concentration, and solvent information is provided with each shipment to support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at the recommended temperature (typically 2-8°C or as specified on the label) to maintain stability. This product is strictly light-sensitive and must be protected from all light exposure during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (HPLC, TLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Concentration	1 mCi/mL in ethanol:water (9:1) or as specified
Solvent	Ethanol:Water (9:1 v/v)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.