Description

7-Methyl-2'-Deoxyguanosine Imidazole (Ring Open) is a chemically modified nucleoside derivative, specifically an open-ring form of a methylated deoxyguanosine. This compound is of significant value as a key intermediate and reference standard in advanced biochemical research and pharmaceutical development. It is primarily needed by research institutions and pharmaceutical companies engaged in nucleoside chemistry, DNA damage and repair studies, and the synthesis of novel therapeutic agents.

Application

• Biochemical Research: Used as a critical intermediate in the study of nucleoside metabolism and DNA modification pathways.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in drug discovery.
• DNA Adduct Studies: Employed in research investigating the formation, detection, and repair of specific alkylated DNA lesions.
• Nucleoside Analog Synthesis: Acts as a specialized building block for the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Enzymology Studies: Utilized as a substrate or inhibitor in enzymatic assays to study the activity of DNA repair enzymes like glycosylases.

Basic Information

Product Name	7-Methyl-2'-Deoxyguanosine Imidazole (Ring Open)
CAS No.	72398-32-4
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	7-Methyl-2'-deoxyguanosine imidazole ring-open form; 2'-Deoxy-7-methylguanosine imidazole; 7-Methyldeoxyguanosine imidazolone; N-(2-Deoxy-β-D-erythro-pentofuranosyl)-2,6-diamino-5-formamido-4-oxopyrimidine; 7-Methyl-dG Imidazole; Open-ring 7-methyl-dG; CAS 72398-32-4
EINECS	Contact for details

Quality Control

Our 7-Methyl-2'-Deoxyguanosine Imidazole (Ring Open) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). A detailed Certificate of Analysis (COA) is provided, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.