Description

Methyl Acetoacetate, [3-14C] CAS NO 71784-42-4 is a carbon-14 labeled isotopologue of methyl acetoacetate, a versatile β-ketoester building block. This radiolabeled compound is essential for conducting precise metabolic and pharmacokinetic studies, enabling researchers to trace the fate of molecules within complex biological systems. It is a critical reagent for scientists in pharmaceutical R&D, agrochemical development, and advanced organic synthesis who require high-specific-activity tracers for autoradiography, ADME (Absorption, Distribution, Metabolism, and Excretion) studies, and reaction mechanism elucidation.

Application

• Pharmaceutical ADME Studies: Used as a radiolabeled precursor or intermediate to synthesize 14C-labeled drug candidates for tracking absorption, distribution, metabolism, and excretion in vivo.
• Metabolic Pathway Tracing: Employed in biochemical research to investigate the metabolic pathways of acetoacetate and related compounds in cellular systems.
• Agrochemical Research: Serves as a labeled starting material for synthesizing radiotracers used in environmental fate studies and metabolism research of pesticides and herbicides.
• Organic Synthesis Intermediate: Acts as a labeled building block in the synthesis of more complex 14C-labeled heterocycles, pharmaceuticals, and fine chemicals.
• Reaction Mechanism Analysis: Utilized in mechanistic studies to identify reaction intermediates and pathways in organic chemistry through isotopic labeling.
• Quality Control & Reference Standard: Can be used as an internal standard or reference material in analytical methods like LC-MS for quantitative analysis.

Basic Information

Product Name	Methyl Acetoacetate, [3-14C]
CAS No.	71784-42-4
Molecular Formula	C5H814CO3 *
Molecular Weight	~117.1 g/mol (depending on specific activity)
Synonyms	3-Oxobutanoic Acid Methyl Ester-3-14C; Methyl 3-Oxobutanoate-3-14C; Acetoacetic Acid Methyl Ester-3-14C; MAA-3-14C; [3-14C]Methyl Acetoacetate; 3-14C-Labeled Methyl Acetoacetate; Methyl 3-[14C]oxobutanoate
EINECS	Contact for details

* The asterisk (14C) denotes the position of the radioactive carbon-14 label.

Quality Control

Every batch of Methyl Acetoacetate, [3-14C] is manufactured and analyzed under strict quality control protocols to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards for radiolabeled compounds. Certificates of Analysis (COA) are provided, detailing key parameters such as radiochemical purity (typically by HPLC), chemical purity, specific activity, and solvent content. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold temperature (e.g., 2-8°C or as specified on the label) to maintain stability and specific activity. Due to its highly volatile nature, ensure containers are securely sealed and stored in a well-ventilated area designated for radioactive materials. Always follow local radiation safety regulations for handling and storage.

Specification

Item	Specification
Appearance	Clear, Colorless to Pale Yellow Liquid
Identification (IR / NMR)	Conforms to Structure
Assay (Radiochemical Purity, HPLC)	≥ 98%
Chemical Purity (GC / HPLC)	≥ 95%
Specific Activity	Customizable (mCi/mmol)
Solvent (if supplied in solution)	Specified on COA
Radioactivity Concentration	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.