Description

(+)-trans-1,2-Cyclohexanedicarboxylic Anhydride is a high-purity, chiral cyclic anhydride of significant industrial importance. This compound serves as a versatile and valuable chiral building block in asymmetric synthesis, enabling the production of optically active intermediates. It is primarily sought after by manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of enantiomerically pure products.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of prostaglandins, antiviral agents, and other optically active drugs.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for biological activity.
• Polymer & Resin Modifier: Acts as a curing agent or a monomer in the synthesis of specialty polyimides, epoxy resins, and alkyd resins, imparting enhanced thermal and mechanical properties.
• Asymmetric Catalyst Ligand Precursor: Employed in the preparation of chiral ligands for metal-catalyzed asymmetric reactions, such as hydrogenation and epoxidation.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex natural products, flavors, and fragrances requiring high stereochemical control.
• Research & Development: Serves as a standard and starting material in academic and industrial R&D laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(+)-trans-1,2-Cyclohexanedicarboxylic Anhydride
CAS No.	71749-03-6
Molecular Formula	C8H10O3
Molecular Weight	154.16 g/mol
Synonyms	(1R,2R)-1,2-Cyclohexanedicarboxylic Anhydride; (R,R)-1,2-Cyclohexanedicarboxylic Anhydride; trans-(+)-1,2-Cyclohexanedicarboxylic Acid Anhydride; (1R,2R)-Cyclohexane-1,2-dicarboxylic Anhydride; Hexahydrophthalic Anhydride, (R,R)-; (R,R)-HHPA; (1R,2R)-HHPA; (+)-trans-Hexahydrophthalic Anhydride
EINECS	Contact for details

Quality Control

Our (+)-trans-1,2-Cyclohexanedicarboxylic Anhydride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets exacting standards for chemical and enantiomeric purity. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.