Description

5(S), 12(R)-Dihete is a high-purity, stereochemically defined leukotriene intermediate. This compound matters for its critical role as a key chiral building block in the synthesis of advanced pharmaceutical agents and bioactive lipid mediators. It is primarily needed by research institutions and pharmaceutical manufacturers focused on developing treatments for inflammatory and immunological conditions, as well as by fine chemical producers requiring precise stereochemical control.

Application

• Key chiral intermediate in the synthesis of leukotriene B4 (LTB4) and related eicosanoids.
• Building block for pharmaceutical research targeting inflammation, asthma, and autoimmune diseases.
• Precursor for labeled compounds (e.g., deuterated, radiolabeled) used in metabolic and pharmacokinetic studies.
• Reference standard for analytical method development and quality control in lipid mediator research.
• Starting material for the preparation of specialized biochemical probes and enzyme inhibitors.
• Used in academic and industrial research to study the 5-lipoxygenase pathway and its biological effects.

Basic Information

Product Name	5(S), 12(R)-Dihete
CAS No.	71652-82-9
Molecular Formula	C20H32O4
Molecular Weight	336.47 g/mol
Synonyms	5(S),12(R)-DiHETE; (5S,12R)-Dihydroxy-6,8,10,14-eicosatetraenoic Acid; 5(S),12(R)-DiHETE; Leukotriene B4 Pathway Intermediate; 5S,12R-DiHETE; (5S,12R)-DiHETE; 5,12-DiHETE (5S,12R isomer)
EINECS	Contact for details

Quality Control

Our 5(S), 12(R)-Dihete is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (5S,12R)
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.