Description

Tryptophan, L-, [Side Chain 1-14C] CAS NO 7762-51-8 is a carbon-14 labeled isotopologue of the essential amino acid L-Tryptophan, specifically radiolabeled at the first carbon of its aromatic side chain. This compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering researchers a precise method to track the incorporation and fate of tryptophan in biological systems. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) engaged in advanced drug discovery, proteomics, and nutritional science.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of tryptophan-containing compounds and biologics.
• Biochemical Pathway Analysis: Essential for tracing metabolic pathways involving tryptophan, such as serotonin, melatonin, and kynurenine biosynthesis, in cell cultures and animal models.
• Protein Synthesis and Turnover Research: Employed to study protein synthesis rates, degradation, and the dynamics of specific tryptophan-rich proteins in vivo.
• Nutritional Science Investigations: Applied in research to understand tryptophan utilization, requirements, and metabolism in various physiological and dietary states.
• Proteomics and Biomarker Discovery: Serves as a reagent in mass spectrometry-based proteomic workflows for quantitative analysis and peptide labeling.
• Radiochemical Reference Standard: Used as an internal standard or calibrant in analytical methods (e.g., LC-MS, scintillation counting) for quantifying tryptophan and its metabolites.

Basic Information

Product Name	Tryptophan, L-, [Side Chain 1-14C]
CAS No.	7762-51-8
Molecular Formula	C11H1214CN2O2
Molecular Weight	~207.2 (for 12C1014C1H12N2O2)
Synonyms	(S)-2-Amino-3-(1-14C-indol-3-yl)propanoic acid; L-Tryptophan-1'-14C; L-Tryptophan (side chain-1-14C); L-Tryptophan-1'-14C (side chain labeled); [1'-14C]-L-Tryptophan; Tryptophan-1-14C (L); 1-14C-L-Tryptophan; L-[1-14C]Tryptophan
EINECS	Contact for details

Quality Control

Every batch of Tryptophan, L-, [Side Chain 1-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity, as well as specific activity consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specifications such as radiochemical purity (by HPLC), chemical purity, specific activity, and solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is both strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). For long-term storage, consider storing desiccated under inert atmosphere. Follow all applicable laboratory safety and radiation safety protocols for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.