Description

Pyruvic Acid, Sodium Salt, [1-14C]- is a carbon-14 labeled isotopologue of sodium pyruvate, a key metabolic intermediate. This radiolabeled compound is essential for precise metabolic pathway tracing and kinetic studies in biochemical research. It is primarily utilized by researchers and scientists in the fields of pharmaceutical development, metabolic research, and tracer studies to investigate cellular energy production, gluconeogenesis, and amino acid synthesis.

Application

• Biochemical Tracer Studies: Used to track the metabolic fate of pyruvate in glycolysis, the citric acid cycle, and anaplerotic reactions.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME studies to elucidate the metabolic pathways of new chemical entities.
• Enzymology Research: Serves as a labeled substrate for assays involving enzymes like lactate dehydrogenase, pyruvate dehydrogenase, and transaminases.
• Medical & Nutritional Research: Applied in studies investigating cellular energetics, ischemia-reperfusion injury, and metabolic disorders.
• Radiochemical Synthesis: Acts as a labeled building block for the synthesis of more complex carbon-14 labeled compounds.

Basic Information

Item	Detail
Product Name	Pyruvic Acid, Sodium Salt, [1-14C]-
CAS No.	7540-66-1
Molecular Formula	C3H314COONa
Molecular Weight	~112.04 g/mol (for labeled form)
Synonyms	Sodium [1-14C]pyruvate; [1-14C]Pyruvic acid sodium salt; Sodium 2-oxo[1-14C]propanoate; NSC 20272; 2-Oxo[1-14C]propionic acid sodium salt; Labeled sodium pyruvate; Carbon-14 labeled sodium pyruvate
EINECS	Contact for details

Quality Control

Every batch of Pyruvic Acid, Sodium Salt, [1-14C]- is manufactured and tested under a strict quality management system. We ensure high radiochemical purity and specific activity through advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and solvent content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Handle and store in accordance with all applicable radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Solvent (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.