Description

Phenylthiohydantoin Alanine (CAS NO 7390-20-7) is a specialized derivative of alanine used as a critical intermediate in peptide and protein chemistry. Its primary value lies in its role in the Edman degradation process, a cornerstone technique for sequencing amino acids in peptides and proteins. This high-purity compound is essential for research institutions, pharmaceutical developers, and biotechnology companies engaged in proteomics, analytical method development, and the synthesis of complex biomolecules.

Application

• Amino Acid Sequencing: A key reagent in the Edman degradation method for stepwise N-terminal amino acid analysis of peptides and proteins.
• Proteomics Research: Used in advanced research laboratories for protein identification, characterization, and structural analysis.
• Analytical Chemistry: Serves as a reference standard and intermediate in the development and validation of HPLC and mass spectrometry methods.
• Biochemical Synthesis: Employed as a building block in the synthesis of modified peptides and other specialized biochemical compounds.
• Pharmaceutical Development: Utilized in R&D for studying protein-drug interactions and in the quality control of biopharmaceuticals.

Basic Information

Product Name	Phenylthiohydantoin Alanine
CAS No.	7390-20-7
Molecular Formula	C10H10N2O2S
Molecular Weight	222.26 g/mol
Synonyms	PTH-Alanine; 3-Phenyl-2-thiohydantoin-5-yl-alanine; 5-(1-Carboxyethyl)-3-phenyl-2-thiohydantoin; Alanine PTH derivative; Edman degradation product of alanine; 2-Thio-5-(1-carboxyethyl)-3-phenyl-4-imidazolidinone; L-Alanine, N-[(phenylamino)thioxomethyl]- (9CI)
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin Alanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research or development protocols upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.