Description

L-Tyrosine-[Ring-3,5-3H] is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-Tyrosine, with the radiolabel specifically incorporated at the 3 and 5 positions of the aromatic ring. This compound is a critical tool for researchers requiring precise metabolic and biochemical pathway tracing in biological systems. It is primarily utilized in pharmaceutical R&D, biochemistry, and molecular biology for advanced studies such as protein metabolism, neurotransmitter synthesis, and receptor binding assays.

Application

• Biochemical Research & Metabolic Pathway Tracing: Used as a radiolabeled tracer to study tyrosine metabolism, protein synthesis, and turnover in cell cultures and animal models.
• Neuropharmacology Studies: Essential for investigating the biosynthesis of catecholamines (dopamine, norepinephrine, epinephrine) and related neurological pathways.
• Receptor Binding & Enzyme Kinetics Assays: Employed in competitive binding studies and enzymatic assays to determine affinity and activity parameters.
• Drug Discovery & Development: Facilitates ADME (Absorption, Distribution, Metabolism, Excretion) studies for new pharmaceutical compounds targeting tyrosine-involved pathways.
• Autoradiography & Imaging: Serves as a probe in histological and biochemical imaging techniques to localize metabolic activity.

Basic Information

Product Name	L-Tyrosine-[Ring-3,5-3H]
CAS No.	7234-03-9
Molecular Formula	C9H93H2NO3 *
Molecular Weight	~183.2 g/mol (for unlabeled base)**
Synonyms	(S)-2-Amino-3-(4-hydroxyphenyl)propionic-3,5-3H2 acid; L-3-(4-Hydroxyphenyl)alanine-[ring-3,5-3H2]; Tritiated L-Tyrosine; [3,5-3H]-L-Tyrosine; H-3 L-Tyrosine; L-Tyrosine (ring-3,5-3H); Tyrosine-3,5-3H2; 4-Hydroxy-L-phenylalanine-3,5-3H2
EINECS	230-625-8 (for unlabeled L-Tyrosine)

* Formula indicates tritium (3H) at the 3 and 5 positions of the aromatic ring. ** Exact molecular weight varies with specific activity.

Quality Control

Every batch of L-Tyrosine-[Ring-3,5-3H] is manufactured and analyzed under strict quality systems. Radiochemical purity and specific activity are determined by validated methods including HPLC with radiometric detection. Certificates of Analysis (COA) detailing specific activity, purity, solvent composition, and analytical chromatograms are provided with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. Follow all applicable local and international regulations for the safe handling and disposal of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC, Co-injection)	Conforms to reference standard
Specific Activity	20-80 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC, UV)	≥ 95%
Solvent	Ethanol:Water (Typically 2:98 v/v) or as specified
Concentration	1 mCi/mL (Contact for exact concentration)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.