Description

Acetyl-D-Glucosamine, n-[Glucosamine-1-14C] is a radiolabeled derivative of N-acetylglucosamine, a fundamental amino sugar and precursor in the biosynthesis of glycoproteins, glycolipids, and glycosaminoglycans. This compound is essential for advanced research requiring precise metabolic tracing and quantification in biochemical pathways. It is primarily utilized by research scientists and pharmaceutical developers in life sciences, particularly for studies in carbohydrate metabolism, glycobiology, and the development of novel therapeutic agents.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the biosynthesis, turnover, and catabolism of hyaluronic acid, chitin, and other glycoconjugates.
• Glycobiology Research: Critical for investigating enzymatic processes involving glycosyltransferases and glycosidases in cell signaling and communication.
• Pharmaceutical R&D: Employed in drug discovery programs targeting osteoarthritis, inflammatory diseases, and cancer, where glucosamine metabolism plays a key role.
• Biochemical Assay Development: Serves as a standard or substrate in enzymatic assays to screen for inhibitors or activators of key biosynthetic enzymes.
• Autoradiography & Imaging Studies: Enables precise localization and visualization of metabolic incorporation in tissue samples or cell cultures.

Basic Information

Product Name	Acetyl-D-Glucosamine, n-[Glucosamine-1-14C]
CAS No.	7220-89-5
Molecular Formula	C8H15NO6 (with 14C label at C-1 of glucosamine moiety)
Molecular Weight	~221.21 g/mol (unlabeled)
Synonyms	N-Acetyl-D-glucosamine-1-14C; 2-Acetamido-2-deoxy-D-glucose-1-14C; D-Glucosamine, N-acetyl-1-14C; N-Acetylglucosamine-1-14C; GlcNAc-1-14C; 2-(Acetylamino)-2-deoxy-D-glucose-1-14C; NAG-1-14C; (2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxane-2-carboxylic acid-1-14C
EINECS	Contact for details

Quality Control

Every batch of Acetyl-D-Glucosamine, n-[Glucosamine-1-14C] is manufactured and analyzed under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity (by HPLC), chemical purity, and solvent composition are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dry, inert atmosphere. Handle and dispose of in accordance with all applicable local, national, and international radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent (for solutions)	Ethanol:Water (Contact for ratio)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.