Description

2'-Deoxyadenosine-8-14C is a carbon-14 labeled nucleoside analog, a critical tool for tracing and quantifying metabolic pathways in biological research. This radiolabeled compound provides unparalleled specificity for studying DNA synthesis, repair mechanisms, and the cellular uptake of nucleosides. It is essential for researchers and manufacturers in the fields of radiopharmaceutical development, biochemical research, and molecular diagnostics, where precise tracking of nucleotide incorporation is required.

Application

• Tracer Studies in Biochemistry & Molecular Biology: Used to investigate the synthesis, turnover, and repair of DNA in cell cultures and in vitro systems.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a radiolabeled standard or intermediate in studies to track the absorption, distribution, metabolism, and excretion (ADME) of nucleoside-based pharmaceuticals.
• Radiopharmaceutical Precursor: Acts as a key labeled building block in the research and development of novel diagnostic imaging agents.
• Enzymology Research: Employed in assays to study the activity and kinetics of enzymes like DNA polymerases, nucleoside kinases, and deaminases.
• Oncology Research: Utilized in research focused on cell proliferation, the mechanism of action of antimetabolite drugs, and cancer metabolism.
• Quality Control & Reference Standard: Functions as an internal standard in analytical methods (e.g., LC-MS) for quantifying deoxyadenosine or related compounds in complex matrices.

Basic Information

Product Name	2'-Deoxyadenosine-8-14C
CAS No.	7074-96-6
Molecular Formula	C₁₀H₁₃¹⁴CN₅O₃
Molecular Weight	Contact for details
Synonyms	9-(2-Deoxy-β-D-erythro-pentofuranosyl)-[8-14C]adenine; [8-14C]-2'-Deoxyadenosine; 2'-Deoxy-[8-14C]adenosine; dA-[8-14C]; Adenine-8-14C deoxyriboside; 2'-Deoxyadenosine (8-14C); 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-[8-14C]purin-6-amine
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxyadenosine-8-14C is produced and analyzed under strict quality systems. We ensure high radiochemical purity and specific activity through advanced analytical techniques including HPLC with radiometric detection. Certificates of Analysis (COA) detailing purity, specific activity, and solvent composition are provided with each shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability. Follow all applicable radiation safety guidelines for storage and handling.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Chemical Purity (HPLC)	≥ 95%
Solvent (for solutions)	Ethanol:Water (7:3) or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.