Description

Gaba Carboxy-14C CAS NO 763-94-0 is a carbon-14 radiolabeled derivative of γ-aminobutyric acid (GABA), a crucial inhibitory neurotransmitter. This isotopically labeled compound is essential for conducting precise metabolic and pharmacokinetic studies, enabling researchers to track the compound's fate in biological systems. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in neuroscience research, drug discovery, and biochemical pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of GABA-related compounds.
• Neuroscience Research: Employed in autoradiography and receptor binding assays to study the localization and function of GABAergic systems in the brain.
• Biochemical Pathway Analysis: Tracks the metabolic fate of GABA and its incorporation into other biomolecules in vitro and in vivo.
• Pharmaceutical Development: Supports the development of novel therapeutics targeting neurological disorders such as epilepsy, anxiety, and insomnia by providing critical metabolic data.
• Environmental Fate Studies: Can be applied in specialized research to trace the environmental degradation pathways of similar chemical structures.

Basic Information

Product Name	Gaba Carboxy-14C
CAS No.	763-94-0
Molecular Formula	C4H914CNO2
Molecular Weight	~105.1 g/mol (for unlabeled); Specific activity provided on COA.
Synonyms	4-Aminobutyric-1-14C acid; GABA-1-14C; γ-Aminobutyric-1-14C acid; 4-Amino[1-14C]butanoic acid; Piperidic-1-14C acid; 763-94-0 (unlabeled CAS); NSC 27425 (unlabeled)
EINECS	212-112-0 (for unlabeled compound)

Quality Control

Every batch of Gaba Carboxy-14C is produced and analyzed under strict quality control protocols to ensure radiochemical purity, chemical purity, and specific activity meet the stringent requirements for research use. Analysis is performed via validated methods including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data on purity, specific activity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dedicated, well-ventilated freezer designated for radiochemicals. Always follow local radiation safety regulations for handling and storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent	Ethanol:Water (specified on COA)
Concentration	1.0 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.