Description

Nortriptyline CAS NO 72-69-5 is a secondary amine tricyclic antidepressant (TCA) of high pharmaceutical importance. It is valued for its established efficacy in the treatment of major depressive disorder and certain neuropathic pain conditions. This active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry producing generic and branded antidepressant formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in antidepressant medications for treating major depressive disorder.
• Neuropathic Pain Management: Formulated in medications for chronic pain conditions such as diabetic neuropathy and post-herpetic neuralgia.
• Generic Drug Manufacturing: Sourcing for cost-effective generic pharmaceutical production to increase market accessibility.
• Clinical Research: Utilized as a reference standard or investigational compound in pharmacological and neurological studies.
• Veterinary Medicine: Potential application in veterinary behavior therapy for certain animal models.
• Formulation Development: Used in R&D for developing novel dosage forms like controlled-release tablets or transdermal patches.

Basic Information

Product Name	Nortriptyline
CAS No.	72-69-5
Molecular Formula	C19H21N
Molecular Weight	263.38 g/mol
Synonyms	Nortriptyline Hydrochloride (salt form); Desmethylamitriptyline; 10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-δ5,γ-propylamine; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene; Allegron; Aventyl; Noritren; Pamelor; Nortrilen
EINECS	200-796-5

Quality Control

Our Nortriptyline is manufactured under strict quality management systems. It is tested to meet relevant pharmacopoeial standards such as USP and EP for identity, purity, and potency. Comprehensive testing includes assay, related substances, residual solvents, and heavy metals analysis. A Certificate of Analysis (COA) is provided with each batch to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, well-ventilated area. Protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.