Description

L-Leucine-Ul-14C is a uniformly carbon-14 labeled isotopologue of the essential branched-chain amino acid L-Leucine. This product is specifically designed for advanced metabolic and pharmacokinetic research, providing a critical tool for tracing biochemical pathways with high precision. It is essential for scientists and researchers in the pharmaceutical, biotechnology, and life science sectors who require reliable radiolabeled tracers for drug development, nutritional studies, and biochemical mechanism elucidation.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities and biologics.
• Biochemical Pathway Analysis: Enables detailed investigation of protein synthesis, amino acid catabolism, and other metabolic fluxes in cell cultures, tissues, and whole organisms.
• Nutritional Research: Applied in studies to understand leucine utilization, muscle protein synthesis, and the metabolic effects of dietary supplements.
• Proteomics and Biomarker Discovery: Facilitates stable isotope labeling techniques (SILAC) for quantitative mass spectrometry-based protein analysis.
• Environmental Fate Studies: Used in research to track the biodegradation and environmental transformation of organic compounds containing leucine structures.
• Medical Imaging Research: Serves as a precursor for developing novel Positron Emission Tomography (PET) radiotracers, although further synthesis is required.

Basic Information

Product Name	L-Leucine-Ul-14C
CAS No.	70-45-1
Molecular Formula	C6H13NO2 (uniformly labeled with 14C)
Molecular Weight	~135.16 g/mol (unlabeled)
Synonyms	(S)-2-Amino-4-methylpentanoic acid-14C; L-2-Amino-4-methylvaleric acid-14C; (S)-Leucine-14C; Leucine (L-isomer)-14C; H-Leu-OH-14C; (S)-2-Amino-4-methylpentanoic acid (uniformly labeled with carbon-14); L-α-Aminoisocaproic acid-14C
EINECS	200-522-0 (for unlabeled compound)

Quality Control

Every batch of L-Leucine-Ul-14C is manufactured and tested under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. We provide comprehensive analytical data, including confirmation by HPLC with radiometric detection and NMR spectroscopy. A detailed Certificate of Analysis (COA) is supplied with each shipment, specifying the exact specific activity, radiochemical purity, and solvent composition. Our quality commitment supports research requiring regulatory compliance for preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container sealed under an inert atmosphere in a dedicated freezer. Always follow local radiation safety regulations for the storage and handling of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Co-elutes with reference standard
Specific Activity	Contact for details
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 98%
Solvent (for solutions)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.