Description

Trifluridine is a fluorinated pyrimidine nucleoside analog with potent antiviral and antineoplastic activity. This compound is a critical active pharmaceutical ingredient (API) valued for its targeted mechanism of action against specific viral and cellular DNA polymerases. It is primarily utilized in the pharmaceutical industry for the formulation of ophthalmic solutions to treat viral keratoconjunctivitis and is also a key intermediate in advanced oncology research. Our supply of Trifluridine CAS NO 70-00-8 ensures high purity and reliable consistency for demanding manufacturing and R&D applications.

Application

• Ophthalmic Antiviral Formulations: Primary active ingredient in topical solutions for the treatment of Herpes simplex virus (HSV) keratitis and keratoconjunctivitis.
• Oncological Research: Investigated as a chemotherapeutic agent and a key intermediate in the synthesis of novel anticancer prodrugs targeting solid tumors.
• Antiviral Drug Development: Serves as a reference standard and building block in the R&D of new antiviral therapies, particularly against DNA viruses.
• Biochemical Research: Used in molecular biology and biochemistry studies to investigate DNA synthesis inhibition and cell proliferation mechanisms.
• Pharmaceutical Intermediates: Critical precursor in the multi-step synthesis of more complex fluorinated nucleoside analogs.

Basic Information

Product Name	Trifluridine
CAS No.	70-00-8
Molecular Formula	C10H11F3N2O5
Molecular Weight	296.20 g/mol
Synonyms	Trifluorothymidine; F3TDR; 5-Trifluoromethyl-2'-deoxyuridine; 2'-Deoxy-5-(trifluoromethyl)uridine; NSC-75520; TFT; Trifluridin; Viroptic (brand name); α,α,α-Trifluorothymidine
EINECS	200-725-2

Quality Control

Our Trifluridine is manufactured under strict quality management systems to meet the rigorous standards of the pharmaceutical industry. Every batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via validated methods such as HPLC and NMR. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure full traceability and compliance with cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.