Description

Elvitegravir is a potent and selective integrase strand transfer inhibitor (INSTI) used in antiretroviral therapy. This active pharmaceutical ingredient (API) is critical for the formulation of combination therapies targeting HIV-1 infection. It is essential for pharmaceutical manufacturers and research institutions developing advanced antiviral treatments and conducting pharmacological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in fixed-dose combination antiretroviral tablets for the treatment of HIV-1 infection in adults and pediatric patients.
• Antiviral Drug Formulation: Key component in the development and commercial production of branded and generic HIV medications, such as in combination with cobicistat, emtricitabine, and tenofovir.
• Biomedical Research: Used as a reference standard and biochemical tool in virology and pharmacology research to study HIV integrase inhibition mechanisms and drug resistance.
• Preclinical & Clinical Development: Serves as a critical material for drug metabolism, pharmacokinetics (DMPK), and toxicology studies during new drug development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of finished dosage forms under cGMP conditions.

Basic Information

Product Name	Elvitegravir
CAS No.	697761-98-1
Molecular Formula	C23H23ClFNO5
Molecular Weight	447.88 g/mol
Synonyms	GS-9137; JTK-303; 6-(3-Chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 4-Quinolinecarboxylic acid, 6-(3-chloro-2-fluorobenzyl)-1-[(1S)-1-hydroxy-3-methylbutyl]-7-methoxy-4-oxo-1,4-dihydro-; Elvitegravirum; UNII-21G32L5T9H
EINECS	Contact for details

Quality Control

Our Elvitegravir is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the highest standards for pharmaceutical use. Quality assurance includes compliance with ICH guidelines and relevant pharmacopeial requirements. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 20 ppm
Loss on Drying	< 1.0%
Residue on Ignition	< 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.