Description

2,3,5,6-Tetrafluoromandelic Acid is a highly functionalized fluorinated mandelic acid derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its unique fluorination pattern imparts distinct electronic and steric properties, making it invaluable for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the fluorine atoms enhance lipophilicity, metabolic stability, and binding affinity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science: Employed in the synthesis of specialty polymers and liquid crystals, where fluorinated aromatic groups influence material properties.
• Chemical Biology Probe Development: Utilized to create fluorinated analogs of natural products or biochemical probes to study enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2,3,5,6-Tetrafluoromandelic Acid
CAS No.	685892-11-9
Molecular Formula	C8H4F4O3
Molecular Weight	224.11 g/mol
Synonyms	2,3,5,6-Tetrafluoro-α-hydroxybenzenacetic acid; (2,3,5,6-Tetrafluorophenyl)(hydroxy)acetic acid; Tetrafluoromandelic acid; α-Hydroxy-2,3,5,6-tetrafluorophenylacetic acid; Mandelic acid, 2,3,5,6-tetrafluoro-; 2,3,5,6-Tetrafluorobenzene glycolic acid
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluoromandelic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R or S enantiomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.