Description

Valopicitabine is a potent and selective nucleoside analog inhibitor of the hepatitis C virus (HCV) RNA polymerase. This compound is a key intermediate in antiviral research and pharmaceutical development, offering significant value for the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on developing next-generation antiviral treatments for HCV and related viral infections.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced antiviral drug candidates targeting Hepatitis C Virus (HCV).
• Antiviral Research: Used in biochemical and virological studies to investigate the mechanism of action of nucleoside analogs against viral polymerases.
• Medicinal Chemistry: Serves as a reference standard and a starting material for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Preclinical Development: Employed in the formulation and efficacy testing of potential anti-HCV therapeutic agents in model systems.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for the production of valopicitabine-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Valopicitabine
CAS No.	640281-90-9
Molecular Formula	C14H19FN4O5
Molecular Weight	342.32 g/mol
Synonyms	NM 283; Valopicitabine dihydrochloride (salt form); 2'-C- Methylcytidine, 3'-O-valinate; 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one 5'-O-L-valinate; 1-(2-C-Methyl-β-D-ribofuranosyl)cytosine 3'-O-L-valinate; HCV Nucleoside Inhibitor NM283
EINECS	Contact for details

Quality Control

Our Valopicitabine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.