Description

Guanidinoacetic-13C2 Acid is a stable isotope-labeled analog of guanidinoacetic acid, where two carbon atoms are replaced with the 13C isotope. This compound is essential as a high-purity internal standard and tracer in quantitative mass spectrometry and metabolic flux analysis. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions engaged in advanced metabolomics, pharmacokinetic studies, and biomarker discovery.

Application

• Internal standard for the precise quantification of endogenous guanidinoacetic acid (GAA) in biological matrices (e.g., plasma, serum, tissue) using LC-MS/MS.
• Tracer compound in metabolic pathway analysis and flux studies to investigate creatine biosynthesis and related disorders.
• Critical reference material in clinical diagnostics and research for conditions related to arginine and glycine metabolism.
• Use in pharmaceutical development for drug metabolism and pharmacokinetic (DMPK) studies of compounds targeting the creatine pathway.
• Component in the manufacturing of certified reference materials (CRMs) and high-purity reagents for analytical laboratories.
• Research tool in nutritional science and sports medicine to study creatine supplementation and energy metabolism.

Basic Information

Product Name	Guanidinoacetic-13C2 Acid
CAS No.	634616-40-3
Molecular Formula	C13CH5N3O2
Molecular Weight	120.07 g/mol (for 13C2 labeled form)
Synonyms	Guanidinoacetic-13C2 Acid; [13C2]-Guanidinoacetic Acid; N-Amidino-13C2-glycine; 2-(Carbamimidamido)-13C2-acetic Acid; GAA-13C2; Glycocyamine-13C2; N-Guanylglycine-13C2; [13C2]-GAA
EINECS	Contact for details

Quality Control

Our Guanidinoacetic-13C2 Acid is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % 13C), chemical purity, and absence of critical impurities. We adhere to relevant standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.