Description

(1S)-2,3-Dihydro-5-Fluoro-1H-Indene-1-Carboxylic Acid is a high-purity, chiral fluorinated indane derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular therapeutics. Pharmaceutical R&D departments and fine chemical manufacturers need this material for its precise stereochemistry and fluorine atom, which are essential for modulating the biological activity, metabolic stability, and bioavailability of target drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates targeting neurological and cardiovascular diseases.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for fluorinated APIs, leveraging the fluorine atom for enhanced drug properties.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals and advanced materials requiring fluorinated indane structures.

Basic Information

Item	Details
Product Name	(1S)-2,3-Dihydro-5-Fluoro-1H-Indene-1-Carboxylic Acid
CAS No.	628732-49-0
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	(1S)-5-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid; (S)-5-Fluoroindane-1-carboxylic acid; (1S)-5-Fluoroindan-1-carboxylic acid; (S)-5-Fluoro-2,3-dihydro-1H-indene-1-carboxylic acid; 5-Fluoro-(1S)-indane-1-carboxylic acid; (S)-Enantiomer of 5-Fluoroindanecarboxylic Acid; Fluorinated Indane Carboxylic Acid; Chiral Fluorinated Building Block
EINECS	Contact for details

Quality Control

Our (1S)-2,3-Dihydro-5-Fluoro-1H-Indene-1-Carboxylic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and assay, to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each batch to guarantee supply reliability and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.