Description

Methyl2-Fluoro-5-Iodobenzoate CAS NO 625471-27-4 is a high-purity fluorinated and iodinated benzoate ester, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique halogenated structure makes it an indispensable building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its versatility in cross-coupling reactions and as a precursor for further functionalization.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and plant growth regulators that require halogenated aromatic cores.
• Material Science Precursor: Employed in the creation of organic electronic materials, liquid crystals, and advanced polymers where fluorine and iodine substitution modulates electronic properties.
• Cross-Coupling Reactions: Serves as a superior substrate in Suzuki-Miyaura, Stille, and other palladium-catalyzed coupling reactions due to the reactive iodine moiety.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in structure-activity relationship (SAR) studies and route scouting.
• Ligand and Catalyst Development: Used to synthesize complex ligands for catalysis or as a model compound in methodological studies.

Basic Information

Product Name	Methyl2-Fluoro-5-Iodobenzoate
CAS No.	625471-27-4
Molecular Formula	C8H6FIO2
Molecular Weight	280.04 g/mol
Synonyms	Methyl 2-Fluoro-5-iodobenzoate; Benzoic acid, 2-fluoro-5-iodo-, methyl ester; 2-Fluoro-5-iodobenzoic acid methyl ester; Methyl 5-iodo-2-fluorobenzoate; 5-Iodo-2-fluorobenzoic acid methyl ester; Methyl o-fluoro-p-iodobenzoate; CAS 625471-27-4
EINECS	Contact for details

Quality Control

Our Methyl2-Fluoro-5-Iodobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.