Description

Riociguat is a potent and selective soluble guanylate cyclase (sGC) stimulator, representing a significant advancement in targeted cardiovascular therapy. Its primary value lies in its ability to directly enhance the nitric oxide-sGC-cyclic guanosine monophosphate (cGMP) pathway, leading to vasodilation and anti-proliferative effects. This makes it a critical active pharmaceutical ingredient (API) for the formulation of medications targeting chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Pharmaceutical manufacturers and research institutions globally require this high-purity compound for drug development and production.

Application

• Primary Pharmaceutical API: Manufacture of finished dosage forms (e.g., tablets) for the treatment of chronic thromboembolic pulmonary hypertension (CTEPH).
• Pulmonary Arterial Hypertension (PAH) Therapy: Key component in medications designed to improve exercise capacity and functional class in PAH patients.
• Clinical Research & Development: Used as a reference standard and active ingredient in preclinical and clinical studies exploring new indications for sGC stimulators.
• Pharmacological Studies: Essential for in-vitro and in-vivo research investigating the cGMP signaling pathway and vascular biology.
• Analytical Reference Standard: Serves as a high-purity calibrant in quality control laboratories for HPLC, LC-MS, or other analytical methods.
• Formulation Development: Used in R&D for developing novel drug delivery systems and optimizing bioavailability.

Basic Information

Product Name	Riociguat
CAS No.	625115-55-1
Molecular Formula	C20H19FN6O2
Molecular Weight	394.40 g/mol
Synonyms	BAY 63-2521; 1-Methyl-6-[2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4-yl]-5-[4-(trifluoromethyl)pyridin-2-yl]-1H-pyrazolo[3,4-b]pyridine-4(5H)-one; Adempas (Brand Name); sGC Stimulator; Soluble Guanylate Cyclase Stimulator
EINECS	Contact for details

Quality Control

Our Riociguat is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to current Good Manufacturing Practices (cGMP) and our quality standards are designed to support regulatory filings in key global markets. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.