Description

2-Pyrrolidinecarbonitrile, 4-Fluoro-1-[2-[(2-Hydroxy-1,1-Dimethylethyl)Amino]Acetyl]-, (2S,4S)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. It is primarily utilized by pharmaceutical R&D departments and contract manufacturing organizations (CMOs) requiring precise chirality and stringent impurity control for next-generation drug development.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of novel, fluorinated pharmaceutical compounds.
• Neurological Drug Development: Used in research and manufacturing of potential therapeutics for central nervous system (CNS) disorders.
• Cardiovascular Drug Candidates: Employed in the synthesis of molecules targeting heart disease and hypertension.
• Protease Inhibitor Research: Functions as a precursor in the development of enzyme inhibitors due to its pyrrolidine scaffold.
• Peptidomimetic Chemistry: Integral for creating stable, bioavailable peptide analogs in medicinal chemistry.
• Asymmetric Synthesis: Provides a chiral template for constructing complex molecules with high enantiomeric purity.

Basic Information

Item	Details
Product Name	2-Pyrrolidinecarbonitrile, 4-Fluoro-1-[2-[(2-Hydroxy-1,1-Dimethylethyl)Amino]Acetyl]-, (2S,4S)-
CAS No.	625110-37-4
Molecular Formula	C11H18FN3O2
Molecular Weight	243.28 g/mol
Synonyms	(2S,4S)-4-Fluoro-1-[2-[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]-2-pyrrolidinecarbonitrile; (4S)-4-Fluoro-1-[(2S)-2-[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]-2-pyrrolidinecarbonitrile; Fluorinated Pyrrolidine Nitrile Intermediate; 4-Fluoro DPP-4 Inhibitor Intermediate; Stereoisomeric Pyrrolidine Derivative
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict cGMP (current Good Manufacturing Practice) guidelines to ensure identity, strength, purity, and quality. Our quality system includes rigorous in-process controls and final release testing. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for chiral purity, chemical purity, and related substances as determined by HPLC, NMR, and other orthogonal methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.