Description

Pradefovir is a potent and selective prodrug of the antiviral nucleotide analog adefovir, designed for targeted delivery and enhanced therapeutic efficacy. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential in treating chronic viral infections. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery and development programs.

Application

• Antiviral Drug Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the research and synthesis of novel antiviral therapeutics.
• Hepatitis B Virus (HBV) Research: Investigated for its potential efficacy against HBV, offering a pathway for next-generation treatments.
• Biochemical Research: Used as a reference standard or probe in studies of nucleotide metabolism and viral polymerase inhibition mechanisms.
• Pharmaceutical Formulation Studies: Employed in pre-formulation and formulation research to develop stable and bioavailable dosage forms.
• Metabolism and Pharmacokinetics Studies: Utilized to understand the prodrug activation pathway, distribution, and elimination profiles in biological systems.

Basic Information

Product Name	Pradefovir
CAS No.	625095-60-5
Molecular Formula	C14H22N6O7P
Molecular Weight	417.34 g/mol
Synonyms	9-[2-[[(Hexyloxy)carbonyl]oxy]ethoxy]methyl]adenine; PMEA Prodrug; Adefovir Dipivoxil Analog; GS-7340 (developmental code); (R)-PMPA Prodrug derivative; 9-(2-Phosphonylmethoxyethyl)adenine prodrug; Hepavir B; Pradefovirum
EINECS	Contact for details

Quality Control

Our Pradefovir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.