Description

R-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol CAS NO 618854-91-4 is a sophisticated, chiral binaphthol derivative featuring electron-withdrawing trifluoromethylphenyl substituents. This compound is a highly valuable ligand and catalyst precursor in asymmetric synthesis, prized for its ability to induce high enantioselectivity in critical bond-forming reactions. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers developing advanced active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., Rh, Ru, Pd) in enantioselective hydrogenation, C-C bond formation, and other catalytic transformations.
• Pharmaceutical Intermediates: Key building block in the synthesis of complex, single-enantiomer drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Chiral Resolution: Used to prepare chiral stationary phases for analytical and preparative chromatography to separate enantiomers.
• Material Science Research: As a monomer or dopant for developing chiral polymers and advanced organic electronic materials with specific optical properties.
• Academic & Industrial R&D: A critical tool for chemists exploring new methodologies in stereoselective organic synthesis.

Basic Information

Product Name	R-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol
CAS No.	618854-91-4
Molecular Formula	C40H26F12O2
Molecular Weight	718.62 g/mol
Synonyms	(R)-H8-BINOL-3,3'-Bis(3,5-Bis(trifluoromethyl)phenyl); (R)-Octahydro-1,1'-bi-2-naphthol derivative; (R)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-bi-2,2'-naphthol (hydrogenated); R-3,3'-Di(3,5-di(trifluoromethyl)phenyl)-H8-BINOL; Chiral BINOL-based ligand; Asymmetric catalyst ligand 618854-91-4; R-DTBM-H8-BINOL
EINECS	Contact for details

Quality Control

Our R-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-H8-BINOL is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for chiral purity and chemical assay, to ensure it meets the exacting standards required for advanced asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which may affect performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.