Description

R-3,3'-Bis(3,5-Dimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol is a sophisticated chiral ligand and building block of significant importance in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in catalytic reactions, which is critical for producing single-enantiomer pharmaceuticals and fine chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, such as hydrogenation, allylic alkylation, and Diels-Alder cycloadditions.
• As a key precursor or resolving agent in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• In the development of novel chiral catalysts for industrial-scale asymmetric synthesis processes.
• For research in organic methodology development focused on creating new carbon-carbon and carbon-heteroatom bonds with high stereoselectivity.
• As a building block for chiral stationary phases used in high-performance liquid chromatography (HPLC) for enantiomer separation.
• In the synthesis of advanced functional materials where chiral architecture dictates optical or electronic properties.

Basic Information

Product Name	R-3,3'-Bis(3,5-Dimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol
CAS No.	618854-90-3
Molecular Formula	C40H40O2
Molecular Weight	552.75 g/mol
Synonyms	(R)-H8-BINOL-DM; (R)-3,3'-Bis(3,5-dimethylphenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol; (R)-Octahydro-3,3'-bis(3,5-dimethylphenyl)-1,1'-binaphthyl-2,2'-diol; (R)-H8-3,3'-(3,5-Dimethylphenyl)-BINOL; R-3,3'-Di(3,5-xylyl)-H8-BINOL; Chiral H8-BINOL Derivative; Asymmetric BINOL Ligand
EINECS	Contact for details

Quality Control

Our R-3,3'-Bis(3,5-Dimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.