Description

(1R,2R)-1,2-Cyclopropanedicarboxylic Acid Monoethyl Ester is a high-purity, chiral cyclopropane derivative that serves as a critical building block in advanced organic synthesis. Its rigid, strained three-membered ring structure and defined stereochemistry make it a valuable intermediate for constructing complex molecules with precise spatial orientation. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Research: Used in the development of stereoselective pesticides and herbicides, where the specific enantiomer can influence biological activity and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis (e.g., hydrogenation, cyclopropanation).
• Material Science: Employed in the research of advanced polymers and liquid crystals, where the cyclopropane ring can impart unique thermal and mechanical properties.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Product Name	(1R,2R)-1,2-Cyclopropanedicarboxylic Acid Monoethyl Ester
CAS No.	613261-14-6
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	(1R,2R)-1,2-Cyclopropanedicarboxylic acid, monoethyl ester; (1R,2R)-Monoethyl cyclopropane-1,2-dicarboxylate; (1R,2R)-Ethyl hydrogen cyclopropane-1,2-dicarboxylate; (1R,2R)-Cyclopropane-1,2-dicarboxylic acid monoethyl ester; trans-(+)-Monoethyl cyclopropane-1,2-dicarboxylate; (1R,2R)-1-Carbethoxycyclopropane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (1R,2R)-1,2-Cyclopropanedicarboxylic Acid Monoethyl Ester is manufactured under strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the stringent requirements for research and development applications. A comprehensive Certificate of Analysis (COA) detailing chiral purity (by chiral HPLC or GC), chemical purity (by HPLC), and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.