Description

1-Cbz-(S)-3-Methylpiperazine is a high-purity, chiral piperazine derivative protected with a carboxybenzyl (Cbz) group. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting the central nervous system. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a chiral ligand or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Peptidomimetics & Drug Discovery: Incorporated into the backbone of peptidomimetic compounds to modulate biological activity and metabolic stability.
• Agrochemical Research: Employed in the development of novel, enantiomerically pure pesticides and herbicides.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and receptor interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high chiral purity and reliable scalability.

Basic Information

Product Name	1-Cbz-(S)-3-Methylpiperazine
CAS No.	612493-87-5
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]-3-methylpiperazine; (S)-1-Carbobenzoxy-3-methylpiperazine; (S)-1-Cbz-3-methylpiperazine; (S)-3-Methyl-1-[(phenylmethoxy)carbonyl]piperazine; 1-[(Benzyloxy)carbonyl]-(3S)-methylpiperazine; N-Cbz-(S)-3-Methylpiperazine; Benzyl (S)-3-methylpiperazine-1-carboxylate; 612493-87-5
EINECS	Contact for details

Quality Control

Our 1-Cbz-(S)-3-Methylpiperazine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, GC, and NMR, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.