Description

Sulbactam Sodium is a potent and highly specific β-lactamase inhibitor, crucial for combating antibiotic resistance. Its primary value lies in its synergistic action with β-lactam antibiotics like ampicillin, restoring their efficacy against resistant bacterial strains. This makes it an essential component for pharmaceutical manufacturers developing combination antibiotic therapies, particularly for hospital-acquired infections. Global demand is driven by the critical need for effective antimicrobial agents in human and veterinary medicine.

Application

• Pharmaceutical Formulations: Key ingredient in fixed-dose combination injectable drugs, most notably with ampicillin (as sultamicillin or ampicillin-sulbactam), for treating a wide range of bacterial infections.
• Antibiotic Potentiation: Used to broaden the spectrum and enhance the potency of penicillin-derived antibiotics by inhibiting bacterial β-lactamase enzymes.
• Hospital Infection Control: Critical for manufacturing antibiotics targeted at multi-drug resistant organisms prevalent in healthcare settings, including skin, intra-abdominal, and gynecological infections.
• Veterinary Medicine: Employed in antibiotic combinations for treating bacterial diseases in livestock and companion animals.
• Research & Development: Serves as a reference standard and active component in microbiological research and the development of new antimicrobial strategies.
• Sterile Injectable Production: Supplied as a high-purity active pharmaceutical ingredient (API) for the aseptic manufacturing of parenteral formulations.

Basic Information

Product Name	Sulbactam Sodium
CAS No.	69388-84-7
Molecular Formula	C8H10NNaO5S
Molecular Weight	255.22 g/mol
Synonyms	Sulbactam Sodium Salt; CP-45,899-2; Sodium Sulbactam; (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide sodium salt; Betamaze; Sulbactam Sodique; UNII-S4TF6I2330; Penicillanic acid sulfone sodium salt
EINECS	Contact for details

Quality Control

Our Sulbactam Sodium is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing parameters such as assay, related substances, residual solvents, and microbiological quality. We can supply material compliant with various pharmacopoeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Recommended long-term storage temperature is between 2°C and 8°C (refrigerated). For short-term use, it may be kept at controlled room temperature (15-25°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (10% solution)	4.5 - 6.5
Water (Karl Fischer)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grade)
Sterility	Sterile (for sterile grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.