Description

Galanthamine Hydrobromide is a high-purity alkaloid salt derived from natural sources, primarily recognized for its potent and selective acetylcholinesterase inhibitory activity. This compound is a critical active pharmaceutical ingredient (API) for the development of neurological therapeutics. It is essential for pharmaceutical manufacturers and research institutions focused on cognitive health and neurodegenerative disease research. The material is supplied under stringent quality control to ensure batch-to-batch consistency for demanding applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of mild to moderate Alzheimer's disease and other memory disorders.
• Neurological Research: A key reference standard and tool compound in preclinical studies investigating cholinergic pathways, neuroprotection, and cognitive function.
• Biochemical Assay Development: Used in vitro for screening and validating new acetylcholinesterase inhibitors and for enzyme kinetics studies.
• Reference Standard: Serves as a high-purity calibrant in analytical laboratories for quality control of finished drug products and raw materials.
• Formulation R&D: Employed in the development of various dosage forms, including tablets, capsules, and controlled-release formulations.
• Veterinary Medicine: Investigated for potential applications in cognitive dysfunction syndrome (CDS) in aging pets.

Basic Information

Product Name	Galanthamine Hydrobromide
CAS No.	69353-21-5
Molecular Formula	C17H21NO3 • HBr
Molecular Weight	368.27 g/mol
Synonyms	Galanthamine HBr; Galantamine Hydrobromide; Lycoramine; Nivalin; Reminyl (as hydrobromide); (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide; Jilkon
EINECS	Contact for details

Quality Control

Our Galanthamine Hydrobromide is manufactured and tested to meet stringent pharmacopeial standards. Every batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure compliance with specifications relevant for pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Specific Rotation	-115° to -125° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.