Description

Thymine, Methyl-D3 is a stable isotope-labeled analog of thymine, a fundamental pyrimidine nucleobase. This deuterated compound is essential for advanced analytical applications where precise molecular tracking and quantification are required. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry and metabolic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS and GC-MS analysis for drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolic Pathway Tracing: Used in stable isotope labeling experiments to investigate nucleic acid synthesis, turnover, and cellular metabolism.
• Pharmaceutical Research & Development: Employed in the synthesis and analysis of deuterated drug candidates to enhance metabolic stability and study biological pathways.
• Biochemical Assay Development: Acts as a key component in developing diagnostic assays and studying enzyme mechanisms involving thymine or thymidine.
• Nucleic Acid Research: Used in studies of DNA damage, repair mechanisms, and the synthesis of modified oligonucleotides.
• Quality Control & Reference Material: Provides a high-purity standard for calibrating analytical instruments and validating methods in quality control laboratories.

Basic Information

Product Name	Thymine, Methyl-D3
CAS No.	68941-98-0
Molecular Formula	C6H4D3N2O2
Molecular Weight	129.13 g/mol
Synonyms	Thymine-methyl-d3; 5-Methyl-d3-uracil; 2,4-Dihydroxy-5-(trideuteriomethyl)pyrimidine; [Methyl-d3]thymine; Thymine-5-methyl-d3; Deuterated Thymine (methyl-d3); 5-(Trideuteriomethyl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our Thymine, Methyl-D3 is produced under strict quality management protocols to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D atom %), chemical purity by HPLC, and identification. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D atom %)	≥ 98.0% (Methyl-d3)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.