Description

Ethyl D-(-)-Pyroglutamate is a high-purity chiral ester derivative of D-pyroglutamic acid, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its defined stereochemistry is essential for producing enantiomerically pure compounds, ensuring high efficacy and specificity in final products. This material is primarily sought by the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis, peptide research, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as a protected or modified amino acid derivative in the synthesis of novel peptides and peptidomimetics.
• Agrochemical Synthesis: Serves as a building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Flavor & Fragrance Industry: Employed in the synthesis of specific chiral flavor compounds and aroma chemicals.
• Biochemical Research: Utilized as a standard or reagent in enzymatic studies and metabolic pathway research.
• Material Science: A potential monomer for synthesizing specialized polymers with unique optical or chiral properties.

Basic Information

Product Name	Ethyl D-(-)-Pyroglutamate
CAS No.	68766-96-1
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	D-(-)-Pyroglutamic Acid Ethyl Ester; Ethyl (R)-(-)-2-Oxopyrrolidine-5-carboxylate; (R)-(-)-Ethyl 5-Oxo-2-pyrrolidinecarboxylate; Ethyl (R)-5-Oxopyrrolidine-2-carboxylate; D-Pyroglutamic Acid Ethyl Ester; (R)-Ethyl 2-Pyrrolidone-5-carboxylate; Ethyl D-Pyroglutamate; (-)-Ethyl 5-Oxo-D-prolinate
EINECS	Contact for details

Quality Control

Our Ethyl D-(-)-Pyroglutamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.