Description

Sulbactam CAS NO 68373-14-8 is a potent and specific β-lactamase inhibitor, crucial for combating antibiotic resistance in modern medicine. Its primary value lies in its synergistic action with β-lactam antibiotics, such as penicillins and cephalosporins, restoring their efficacy against resistant bacterial strains. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced antibacterial formulations, particularly for injectable and combination therapies targeting serious infections.

Application

• Pharmaceutical API: Core component in the synthesis of combination antibiotic drugs like ampicillin/sulbactam and cefoperazone/sulbactam.
• β-Lactamase Inhibition: Used to protect susceptible β-lactam antibiotics from degradation by bacterial enzyme β-lactamase, extending their spectrum of activity.
• Hospital Infection Treatment: Critical for formulating injectable treatments for intra-abdominal, skin, gynecological, and other hospital-acquired infections.
• Veterinary Medicine: Employed in veterinary pharmaceuticals to treat bacterial infections in animals.
• Biochemical Research: Serves as a key reference standard and tool in microbiological and enzymatic research on antibiotic resistance mechanisms.
• Drug Development: Used in R&D for developing new antibiotic combinations and evaluating their potency against multi-drug resistant bacteria.

Basic Information

Product Name	Sulbactam
CAS No.	68373-14-8
Molecular Formula	C8H11NO5S
Molecular Weight	233.24 g/mol
Synonyms	Penicillanic Acid Sulfone; CP-45,899; (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-Dioxide; Sulbactam Acid; Betamaze; Sulbactamum; UNII-S4TF6I2330; Sulfabactam
EINECS	269-919-4

Quality Control

Our Sulbactam is manufactured under strict quality systems. It undergoes rigorous analytical testing, including HPLC, IR, and loss on drying, to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, impurities, and other critical parameters. We support compliance with major pharmacopoeial standards, including USP and EP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	+223° to +237° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.