Description

L-Aspartic Acid (3-13C) is a stable isotope-labeled analog of the essential amino acid L-aspartic acid, where the carbon atom at the 3-position is enriched with the carbon-13 isotope. This compound is a critical tool for advanced research and development, enabling precise metabolic pathway tracing and quantitative analysis in complex biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and nutritional science sectors for applications in drug metabolism studies, proteomics, and the development of isotopically labeled standards.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism, glycolysis, and the TCA cycle in cell cultures and microorganisms.
• Drug Discovery & Development: Employed in pharmacokinetic and pharmacodynamic (PK/PD) studies to track the metabolic fate of drug candidates containing aspartic acid moieties.
• Proteomics & Mass Spectrometry: Serves as an internal standard for the accurate quantification of proteins and peptides via techniques like LC-MS/MS, improving data reliability.
• Nutritional Research: Applied in studies investigating amino acid metabolism, protein synthesis rates, and nutritional bioavailability in humans and animals.
• Biochemical Synthesis: Acts as a labeled precursor for the enzymatic or chemical synthesis of other isotopically labeled compounds and biomolecules.
• NMR Spectroscopy: Provides a distinct signal in Nuclear Magnetic Resonance studies for structural elucidation and dynamic analysis of biomolecules.

Basic Information

Product Name	L-Aspartic Acid (3-13C)
CAS No.	68261-19-8
Molecular Formula	C4H7NO4 (with 13C at position 3)
Molecular Weight	134.10 g/mol (for 13C labeled form)
Synonyms	(2S)-2-Aminobutanedioic-3-13C acid; L-Aspartic-3-13C acid; (S)-Aminosuccinic-3-13C acid; Aspartic acid-3-13C; H-Asp(3-13C)-OH; 13C-L-Aspartic Acid; L-2-Aminobutanedioic-3-13C acid; Isotope-labeled L-aspartate
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid (3-13C) is produced under strict quality management protocols. Each batch is characterized to ensure high chemical purity and isotopic enrichment, typically exceeding 99% chemical purity and 99 atom % 13C. Certificates of Analysis (COA) are provided, detailing results for identity, assay, isotopic enrichment, specific rotation, and impurity profiles via advanced analytical techniques including HPLC, NMR, and MS. We support compliance with cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 99.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Specific Rotation	+24.5° to +26.0° (c=1 in 5N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.