Description

1-Aminocyclohexane-1-Carboxylic Acid, [Carboxyl-14C] is a carbon-14 labeled derivative of the non-proteinogenic amino acid, 1-aminocyclohexanecarboxylic acid (ACHC). This isotopically labeled compound is a critical tool for metabolic and pharmacokinetic studies, providing researchers with a precise tracer to follow the fate of the parent molecule in biological systems. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in drug discovery and development, particularly for investigating the absorption, distribution, metabolism, and excretion (ADME) of novel therapeutic candidates.

Application

• ADME (Absorption, Distribution, Metabolism, Excretion) Studies: Used as a radiolabeled tracer to quantitatively track the metabolic pathways and clearance of drug candidates in preclinical models.
• Pharmacokinetic (PK) Profiling: Essential for determining key PK parameters such as bioavailability, half-life, and tissue distribution of compounds containing the ACHC moiety.
• Metabolite Identification & Profiling: Facilitates the detection, isolation, and structural elucidation of metabolites formed in in vitro and in vivo systems.
• Bioconjugation & Radioligand Development: Serves as a building block for synthesizing radiolabeled peptides, proteins, or other biomolecules for imaging or targeting studies.
• Mechanistic Biochemical Research: Enables detailed investigation into enzyme mechanisms and biochemical pathways involving this specific amino acid structure.
• Environmental Fate Studies: Applied in specialized research to trace the environmental degradation and persistence of related chemical entities.

Basic Information

Product Name	1-Aminocyclohexane-1-Carboxylic Acid, [Carboxyl-14C]
CAS No.	68141-40-2
Molecular Formula	C7H13NO2 (with 14C label at the carboxyl carbon)
Molecular Weight	~143.18 g/mol (exact mass depends on specific activity)
Synonyms	ACHC, [Carboxyl-14C]; 1-Amino-1-cyclohexanecarboxylic acid-14C; Cycloleucine-14C (carboxyl-labeled); (1-Aminocyclohexyl)carboxylic-14C acid; NSC 1026-14C; 1-Aminocyclohexanecarboxylic-1-14C acid; Aminocyclohexanecarboxylic Acid-14C; 1-Amino-cyclohexanecarboxylic acid (carboxyl-14C)
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled materials is produced and analyzed under strict quality control protocols to ensure radiochemical purity, chemical purity, and specific activity meet the exacting standards required for scientific research. Production adheres to relevant cGMP guidelines for advanced intermediates. A comprehensive Certificate of Analysis (CoA) is provided with each shipment, detailing analytical results from techniques such as HPLC with radiometric detection, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment after each use. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Customizable (mCi/mmol range)
Solvent (if supplied as solution)	Specified on CoA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.